Essential oils for COVID-19 management: A systematic review of randomized controlled trials


  • Teuku F. Duta Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia
  • Diva R. Rizki Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia
  • Agnia Purnama Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, Indonesia
  • Marius Rademaker Clinical Trial New Zealand, Waikato Hospital Campus, Hamilton, New Zealand
  • Uwe Wollina Department of Dermatology and Allergology, Städtisches Klinikum Dresden, Academic Teaching Hospital, Dresden, Germany
  • Yogesh Acharya Western Vascular Institute, Galway University Hospital, Galway, Ireland
  • Ziad Abdeen Department of Community Health, Faculty of Medicine, Al-Quds University, East Jerusalem, Palestine
  • Sandro G. V. Rosa Division of Pharmacy, National Institute of Industrial Property, Rio de Janeiro, Brazil
  • Henning B. Nielsen Department of Anesthesia and Intensive Care, Zealand University Hospital Roskilde, Roskilde, Denmark; Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Denmark
  • Kannan Subbaram School of Medicine, The Maldives National University, Maldives



Volatile compound, aromatherapy, COVID-19, SARS-CoV-2 infection, respiratory tract infection


Essential oils can be a beneficial adjuvant therapy in managing coronavirus disease 2019 (COVID-19). This systematic review aims to evaluate the efficacy of essential oils in ameliorative COVID-19-related symptoms. Published studies reporting the efficacy of essential oils as adjuvant therapy for COVID-19 were screened on Scillit, Scopus, SciFinder, and PubMed (December 7th, 2022). Inclusion criteria include the randomized controlled trials (RCTs) participated by those diagnosed with COVID-19 and treated with essential oils as adjuvant therapy. Quality assessment was carried out using Cochrane ‘risk-of-bias’ 2.0 tool. A total of 2112 records were retrieved from the initial screening, which was reduced to four publications (n=344 individuals). The foregoing studies reported that essential oils could improve the recovery rate, alleviate post-COVID-19 fatigue, and prevent disease progression. Regarding their potential antiviral activity, better designed studies are needed. In conclusion, essential oils as adjuvant therapy are beneficial in ameliorating mild COVID-19 symptoms.






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